Innovación, Investigación y Salud
Jun. 3, 2022![](https://chilealimentos.com/wp-content/uploads/2022/06/pinas_699px.jpg)
Científicos descubren que un compuesto de la piña puede ayudar a combatir el SARS-COVID
In a recent study posted to the bioRxiv* preprint server, scientists demonstrated that the pineapple-derived jacalin-related lectin (AcmJRL/AnLec) could be an anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) agent.
With approximately 529 million global SARS-CoV-2 cases identified to date, the current CoV disease 2019 (COVID-19) pandemic has emerged as one of the substantially challenging global health risks. Complementary to COVID-19 vaccines, innovative medications have been the topic of studies and development. SARS-CoV-2’s highly glycosylated spike (S) protein is a primary focus for antiviral medicines since it aids in infection.
In the present work, the scientists ascribed the ligand selectivity of AcmJRL using glycan array assessment, characterized its contact with carbohydrates, and confirmed high-mannose glycans as AcmJRL’s favored ligands. The AcmJRL’s ligand selectivity was elucidated using two glycan arrays, Semiotik and Consortium for Functional Glycomics (CFG) glycan arrays. In addition, the engagement of AcmJRL with carbohydrates was evaluated in a competitive binding assessment. The authors evaluated the attachment of AcmJRL to recombinantly generated S protein and its derived receptor-binding domain (RBD) because the SARS-CoV-2 S protein was found previously to include a large proportion of high-mannose N-glycans.
Medical News Today/May 31, 2022