Innovación, Investigación y Salud
Ago. 25, 2022![](https://chilealimentos.com/wp-content/uploads/2022/08/uvas2_699PX.jpg)
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In a recent study published in the journal Foods, eating grapes can extend life expectancy by five years and reduce non-alcoholic fatty liver disease risk in mice fed high-fat diets.
Background
Nutrition plays an essential role in maintaining health, avoiding disease onset, and improving longevity. The basic concept of a healthy diet includes higher consumption of vegetables, fruits, and whole grains and lower consumption of trans-fat, saturated fats, and refined carbohydrates. According to the US Department of Agriculture economics research service, a daily diet should include at least two cups of fruit and 2.5 cups of vegetables.
Vegetables and fruits are vital for maintaining the body’s homeostasis and ameliorating pathological conditions. In recent years, evidence has accumulated that vegetables and fruits can modulate gene expression and regulate metabolic pathways.
Grapes are considered wonder fruits. The bioactive components of grapes are known to modulate the pathophysiology of various diseases, including diabetes, obesity, cancer, and inflammatory diseases. In addition, grape components are also known to control the aging process and improve longevity.
In the current study, the scientists have evaluated the efficacy of grapes in mitigating adverse health effects induced by a high-fat western-pattern diet.
A diet rich in saturated fats, refined carbohydrates, and salt increases the risk of obesity, cardiovascular disease, and metabolic diseases, such as diabetes and non-alcoholic fatty liver disease. The diet is also known to reduce the lifespan of mice by 34%.
The scientists specifically aimed to understand the impact of grape consumption on hepatic gene expression, lipid metabolism, longevity, and non-alcoholic fatty liver disease. Mice fed with a 5% grape powder-supplemented high-fat diet or semi-synthetic diet were used as experimental models.
The supplementation of mice with 5% grape powder was estimated to be equivalent to the daily consumption of about 300 gm of fresh grapes by a person weighing 70 kg.
NewsMedical.net/August 24, 2022